Photocontrolled DNA Binding of a Receptor-Targeted Organometallic Ruthenium(II) Complex
نویسندگان
چکیده
منابع مشابه
Photocontrolled DNA binding of a receptor-targeted organometallic ruthenium(II) complex.
A photoactivated ruthenium(II) arene complex has been conjugated to two receptor-binding peptides, a dicarba analogue of octreotide and the Arg-Gly-Asp (RGD) tripeptide. These peptides can act as "tumor-targeting devices" since their receptors are overexpressed on the membranes of tumor cells. Both ruthenium-peptide conjugates are stable in aqueous solution in the dark, but upon irradiation wit...
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ژورنال
عنوان ژورنال: Journal of the American Chemical Society
سال: 2011
ISSN: 0002-7863,1520-5126
DOI: 10.1021/ja205235m